Men’s Health Advisor - Reflux drugs may raise risk of hip fracture
Acid-suppressing drugs known as proton pump inhibitors (PPIs), frequently prescribed for people with gastroesophageal reflux disease, may raise the risk of hip fracture, according to a study in the Dec. 27 issue of the Journal of the American Medical Association. PPIs include esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix) and rabeprazole (Aciphex).
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Researchers collected data on 13,556 hip-fracture patients and 135,386 healthy people, all age 50 and older, and found that patients taking a PPI for more than a year had a 44 percent increased risk of hip fracture, compared with those not taking the drug. Additionally, people on long-term PPI therapy were more than 2.6 times more likely to suffer a hip fracture, the researchers reported, and the risk grew with increased duration and dosage of PPI treatment. The study authors recommended that doctors re-emphasize increased calcium intake, preferably from a dairy source, for older patients on long-term and high-dose PPI therapy.
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